Anti-androgenic activities of Ganoderma lucidum.

نویسندگان

  • Rumi Fujita
  • Jie Liu
  • Kuniyoshi Shimizu
  • Fumiko Konishi
  • Kiyoshi Noda
  • Shoichiro Kumamoto
  • Chie Ueda
  • Hisatoshi Tajiri
  • Shuhei Kaneko
  • Yoshitaro Suimi
  • Ryuichiro Kondo
چکیده

The inhibitory effects of methanol extracts of 19 edible and medicinal mushrooms on 5alpha-reductase activity were examined. The extract of Ganoderma lucidum Fr. Krast (Ganodermataceae) showed the strongest 5alpha-reductase inhibitory activity. The treatment of the fruit body of Ganoderma lucidum or the extract prepared from it significantly inhibited the testosterone-induced growth of the ventral prostate in castrated rats. These results showed that Ganoderma lucidum might be a useful ingredient for the treatment of benign prostatic hyperplasia (BPH).

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عنوان ژورنال:
  • Journal of ethnopharmacology

دوره 102 1  شماره 

صفحات  -

تاریخ انتشار 2005